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Hematopoietic stem cells: the paradigmatic tissue-specific stem cell

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Author

Summary, in English

The recent prospective isolation of a wide variety of somatically derived stem cells has affirmed the notion that homeostatic maintenance of most tissues and organs is mediated by tissue-specific stem and progenitor cells and fueled enthusiasm for the use of such cells in strategies aimed at repairing or replacing damaged, diseased, or genetically deficient tissues and organs. Hematopoietic stem cells (HSCs) are arguably the most well-characterized tissue-specific stem cell, with decades of basic research and clinical application providing not only a profound understanding of the principles of stem cell biology, but also of its potential pitfalls. It is our belief that emerging stem cell fields can benefit greatly from an understanding of the lessons learned from the study of HSCs. In this review we discuss some general concepts regarding stem cell biology learned from the study of HSCs with a highlight on recent work pertaining to emerging topics of interest for stem cell biology.

Department/s

  • Immunology

Publishing year

2006

Language

English

Pages

338-346

Publication/Series

American Journal of Pathology

Volume

169

Issue

2

Document type

Journal article

Publisher

American Society for Investigative Pathology

Topic

  • Cell and Molecular Biology

Status

Published

Research group

  • Immunology

ISBN/ISSN/Other

  • ISSN: 1525-2191