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Familial and hormonal risk factors for papillary serous uterine cancer

På svenska

Author

  • L Elit
  • T Pal
  • R Goshen
  • Helena Jernström
  • I Ackerman
  • A Fyles
  • M Carey
  • M Mitchell
  • J Aube
  • SA Narod

Summary, in English

Objectives: To identify genetic and non-genetic risk factors for papillary serous uterine cancer. Methods: A case-control study was conducted. Case women with papillary serous uterine cancer were compared with two control groups: 1) women with endometrioid uterine cancer and 2) healthy women with no past history of cancer. Cases and controls were matched for age (within two years) and ethnic group. All study subjects completed a questionnaire addressing family history. The cases and healthy controls were assessed for factors associated with estrogen exposure. Results: The risks of breast cancer (RR 1.84, Cl 1.03-331) and of prostate cancer (RR 2.21, CI 0.77-6.37) were higher among the relatives of patients with papillary serous uterine cancer, than among relatives of those with endometrioid uterine cancer. Other significant risk factors included weight at 18 years (p = 0.04) and the use of estrogen replacement therapy (p = 0.04). Conclusion: Relatives of women with papillary serous cancer of the uterus had an increased risk of breast and prostate cancer. Hormonal exposure also increases the risk for this cancer. These Findings suggest that predisposing genetic factors, possibly related to hormone metabolism, may be common to the three forms of cancer.

Publishing year

2002

Language

English

Pages

187-190

Publication/Series

European Journal of Gynaecological Oncology

Volume

23

Issue

3

Document type

Journal article

Publisher

SOG Canada.

Topic

  • Cancer and Oncology

Keywords

  • hormonal risk factors
  • papillary serous uterine cancer

Status

Published

ISBN/ISSN/Other

  • ISSN: 0392-2936