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Lewis blood group antigens in urine sediments from patients with urinary bladder carcinoma

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Author

  • S Mårtensson
  • T Brodin
  • Alan Chester
  • Stig Colleen
  • A Lundblad

Summary, in English

Urine sediments from 20 patients with urinary bladder carcinoma, and from 11 healthy individuals were investigated for their content of Lea and Leb active glycolipids. The investigation was restricted to blood group phenotype Le (a-b+). All individuals exhibited both Lea- and Leb-active glycolipids. In healthy individuals the ratio Lea/Leb was less than 1 in 10 out of 11 cases, whereas in patients with bladder cancer the ratio Lea/Leb was greater than 1 in 11 out of 20 cases. No correlation between the Lea/Leb ratio on the one hand and tumour grade or stage on the other hand could be shown. The results indicate one possible explanation for the loss of ABH antigens in bladder cancer and also demonstrate the potential of detailed biochemical investigations on exfoliated material in urine.

Publishing year

1987

Language

English

Pages

197-201

Publication/Series

Scandinavian Journal of Urology and Nephrology

Volume

21

Issue

3

Document type

Journal article

Publisher

Taylor & Francis

Topic

  • Hematology

Status

Published

Research group

  • Urology

ISBN/ISSN/Other

  • ISSN: 0036-5599