Closed-loop Prevention of Hypotension in the Heartbeating Brain-dead Porcine Model
Author
Summary, in English
Objective: The purpose of this paper is to demonstrate feasibility of a novel closed-loop controlled therapy for prevention of hypertension in the heartbeating brain-dead porcine model.
Methods: Dynamic modeling and system identification were based on in-vivo data. A robust controller design was obtained for the identified models. Disturbance attenuation properties, and reliability of operation of the resulting control system, were evaluated in vivo. Results: The control system responded both predictably and consistently to external disturbances. It was possible to prevent mean arterial pressure to fall below a user-specified reference throughout 24 h of completely autonomous operation.
Conclusion: Parameter variability in the identified models confirmed the benefit of closed-loop controlled administration of the proposed therapy. The evaluated robust controller was able to mitigate both process uncertainty and external disturbances.
Significance: Prevention of hypertension is critical to the care of heartbeating brain-dead organ donors. Its automation would likely increase the fraction of organs suitable for transplantation from this patient group.
Methods: Dynamic modeling and system identification were based on in-vivo data. A robust controller design was obtained for the identified models. Disturbance attenuation properties, and reliability of operation of the resulting control system, were evaluated in vivo. Results: The control system responded both predictably and consistently to external disturbances. It was possible to prevent mean arterial pressure to fall below a user-specified reference throughout 24 h of completely autonomous operation.
Conclusion: Parameter variability in the identified models confirmed the benefit of closed-loop controlled administration of the proposed therapy. The evaluated robust controller was able to mitigate both process uncertainty and external disturbances.
Significance: Prevention of hypertension is critical to the care of heartbeating brain-dead organ donors. Its automation would likely increase the fraction of organs suitable for transplantation from this patient group.
Department/s
Publishing year
2017
Language
English
Pages
1310-1317
Publication/Series
IEEE Transactions on Biomedical Engineering
Volume
64
Issue
6
Full text
- Available as PDF - 509 kB
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Document type
Journal article
Publisher
IEEE - Institute of Electrical and Electronics Engineers Inc.
Topic
- Control Engineering
- Anesthesiology and Intensive Care
- Other Medical Engineering
Keywords
- Drug delivery, Medical control systems
Status
Published
Project
- Hemodynamic Stabilization
Research group
- Heart and Lung transplantation
- Cardiopulmonary disease - information, support and reception
- LCCC
ISBN/ISSN/Other
- ISSN: 1558-2531