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Feasibility of in vivo N-15 MRS detection of hyperpolarized N-15 labeled choline in rats

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Author

  • Cristina Cudalbu
  • Arnaud Comment
  • Fiodar Kurdzesau
  • Ruud B. van Heeswijk
  • Kai Uffmann
  • Sami Jannin
  • Vladimir Denisov
  • Deniz Kirik
  • Rolf Gruetter

Summary, in English

The increase of total choline in tumors has become an important biomarker in cancer diagnosis. Choline and choline metabolites can be measured in vivo and in vitro using multinuclear MRS. Recent in vivo C-13 MRS studies using labeled substrates enhanced via dynamic nuclear polarization demonstrated the tremendous potential of hyperpolarization for real-time metabolic studies. The present study demonstrates the feasibility of detecting hyperpolarized N-15 labeled choline in vivo in a rat head at 9.4 T. We furthermore report the in vitro (172 +/- 16 s) and in vivo (126 +/- 15 s) longitudinal relaxation times. We conclude that with appropriate infusion protocols it is feasible to detect hyperpolarized N-15 labeled choline in live animals.

Publishing year

2010

Language

English

Pages

5818-5823

Publication/Series

Physical Chemistry Chemical Physics

Volume

12

Issue

22

Document type

Journal article

Publisher

Royal Society of Chemistry

Topic

  • Neurosciences

Status

Published

Research group

  • Brain Repair and Imaging in Neural Systems (BRAINS)

ISBN/ISSN/Other

  • ISSN: 1463-9084