Surface proteins of the Group G Streptococcus in different phases of growth: patterns of production and implications for the host-bacteria relationship.
Author
Summary, in English
Group G streptococcus (GGS) is a human bacterial pathogen expressing surface proteins FOG and protein G (PG) which interact with several host defense systems, including the complement and contact systems. Selected reaction monitoring mass spectrometry, electron microscopy, and protein binding assays were used to follow the amounts of FOG and PG intracellularly and on the bacterial surface during different phases of growth. Large and increasing amounts of PG were present on the surface in the stationary growth phase, and this was due to de novo production. In contrast, the amount of FOG did not change substantially during this phase. Apart from PG, a number of housekeeping proteins also increased in abundance in the stationary phase. These results show that GGS protein production is active during the stationary phase and that the bacteria actively remodel their surface and enter a less pro-inflammatory state in this phase.
Publishing year
2014
Language
English
Pages
279-286
Publication/Series
Microbiology
Volume
160
Issue
Nov 12
Links
Document type
Journal article
Publisher
MAIK Nauka/Interperiodica
Topic
- Infectious Medicine
Status
Published
Research group
- Infection Medicine Proteomics
ISBN/ISSN/Other
- ISSN: 1465-2080