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Chemical characterization of cyanogen bromide fragments from the beta-chain of human complement factor C3

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Author

Summary, in English

The isolated beta-chain of human complement factor C3 (C3 beta) was fragmented by cyanogen bromide. Nine fragments were defined by gel filtration and high-pressure liquid chromatography, and characterized with respect to their Mr, amino acid composition and N-terminal amino acid sequence. Approx. 30% of the primary structure of C3 beta was determined. Alignment of the 3 N-terminal fragments allowed determination of 61 of the amino terminal residues of C3 beta. This region demonstrated 40% homology with the sequence in the N-terminal segment of the alpha-chain of the cobra venom factor.

Publishing year

1984

Language

English

Pages

57-62

Publication/Series

FEBS Letters

Volume

169

Issue

1

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Medicinal Chemistry

Keywords

  • *Cyanogen Bromide
  • Complement C3/*analysis
  • High Pressure Liquid
  • Gel
  • Chromatography
  • Amino Acid Sequence
  • Amino Acids/analysis
  • Humans
  • Peptide Fragments/*analysis
  • Research Support
  • Non-U.S. Gov't

Status

Published

ISBN/ISSN/Other

  • ISSN: 1873-3468