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Clinical system for interstitial photodynamic therapy with combined on-line dosimetry measurements

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Author

Summary, in English

A system for interstitial photodynamic therapy with delta-aminolaevulinic acid and multiple optical fibers has been developed. The system enables photodynamic treatment of large embedded tumor volumes and utilizes real-time measurements to allow on-line dosimetry. Important parameters such as light fluence rate, sensitizer fluorescence intensity, and changes in local blood oxygen saturation are measured with the same fibers that deliver the therapeutic light. Data from the first clinical treatments on nodular basal cell carcinomas indicate a major treatment-induced light absorption increase, rapid sensitizer photo-bleaching, and a relatively constant global tissue oxygen saturation level during the treatment.

Publishing year

2005

Language

English

Pages

4023-4031

Publication/Series

Applied Optics

Volume

44

Issue

19

Document type

Journal article

Publisher

Optical Society of America

Topic

  • Cancer and Oncology
  • Dermatology and Venereal Diseases

Status

Published

ISBN/ISSN/Other

  • ISSN: 2155-3165