Long-term retention of neurotoxic beta-carbolines in brain neuromelanin

Summary, in English

beta-Carbolines show structural resemblance to the neurotoxic N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and are metabolized to mitochondrial toxicants. Humans are continuously exposed to low levels of beta-carbolines through cooked food, coffee, alcoholic beverages and tobacco smoke. beta-Carbolines have previously been detected in higher levels in the pigmented substantia nigra than in the cortex of humans. The distribution of H-3-labelled harman and norharman in the brain of pigmented and albino mice and in frogs (a species having neuromelanin) was studied by tape-section and light-microscopic autoradiography. Furthermore, the binding of these beta-carbolines to dopamine-melanin and melanin granules from Sepia officinalis was examined. The results revealed a high affinity binding to melanin and a long-term retention (up to 30 days) in pigmented tissues, including neuromelanin-containing neurons of frogs after a single injection. The role of long-term exposure to food-related beta-carbolines and a retention of these compounds in pigment-containing neurons in the induction of idiopathic Parkinson's disease should be further considered.

• Author: A Ostergren; A Annas; Kerstin Skog; N G Lindquist; E B Brittebo
• Department/s: Division of Food and Pharma
• Publishing year: 2004
• Language: English
• Pages: 141-157
• Publication/Series: Journal of Neural Transmission
• Volume: 111
• Issue: 2
• Links: http://dx.doi.org/10.1007/s00702-003-0080-0
• Document type: Journal article
• Publisher: Springer
• Topic: Neurology
• Keywords: b-Carbolines; parkinsonism; neuromelanin; harman; norharman; Parkinson’s disease; dopamine–melanin; Sepia officinalis
• Status: Published
• ISBN/ISSN/Other: ISSN: 0300-9564