Treatment of the overactive bladder: possible central nervous system drug targets.
Author
Summary, in English
The well-known side effects of antimuscarinic drugs have focused interest on other modalities of treatment of the overactive bladder. To effectively control bladder activity, identification of suitable targets for pharmacologic intervention is necessary. Such targets may be found in the central nervous system (CNS) or peripherally. Several CNS transmitters may modulate voiding, but few drugs with a defined CNS site of action have been developed for treatment of voiding disorders. Drugs affecting gamma-aminobutyric acid, opioid, serotonin, noradrenaline, dopamine, or glutamatergic receptors and mechanisms are known to influence micturition, and potentially such drugs could be developed for clinical use. However, a selective action on the lower urinary tract may be difficult to obtain.
Department/s
Publishing year
2002
Language
English
Pages
18-24
Publication/Series
Urology
Volume
59
Issue
5 Suppl 1
Links
Document type
Journal article
Publisher
Elsevier
Topic
- Urology and Nephrology
Keywords
- Bladder Diseases : physiopathology
- Bladder Diseases : drug therapy
- Dopamine : physiology
- Human
- Muscarinic Antagonists : therapeutic use
- Norepinephrine : physiology
- Support
- Serotonin : physiology
- Non-U.S. Gov't
- gamma-Aminobutyric Acid : physiology
Status
Published
ISBN/ISSN/Other
- ISSN: 1527-9995