Pyridoxine reduces cholesterol and low-density lipoprotein and increases antithrombin III activity in 80-year-old men with low plasma pyridoxal 5-phosphate
Author
Summary, in English
We have previously observed that pyridoxine treatment reduced plasma total cholesterol (TC) and low-density lipoprotein (LDL) cholesterol concentrations and increased antithrombin III (AT III) activity in atherosclerotic patients with subnormal plasma pyridoxal 5-phosphate (PLP) levels. In order to confirm these results, we selected 17 males with low plasma PLP levels from a group of 122 80-year-old males in whom PLP has been determined. After supplementation with 120 mg of pyridoxine per day for 8 weeks their mean plasma TC and LDL cholesterol concentrations were decreased by 10% (p less than 0.01) and 17% (p less than 0.001), respectively. There was no effect on high-density lipoprotein cholesterol and triglycerides but plasma AT III activity was increased by 6% (p less than 0.05). The mechanism by which pyridoxine acts is unclear but it is hypothesized that pyridoxine-derived PLP may enhance the catabolism of LDL and the activity of AT III by inhibiting their glycosylation.
Department/s
Publishing year
1990-12
Language
English
Pages
873-877
Publication/Series
Scandinavian Journal of Clinical & Laboratory Investigation
Volume
50
Issue
8
Document type
Journal article
Publisher
Informa Healthcare
Topic
- Gerontology, specializing in Medical and Health Sciences
- Pharmacology and Toxicology
- Cardiac and Cardiovascular Systems
- Neurology
- Medicinal Chemistry
Keywords
- cholesterol
- pyridoxal 5-phosphate
- antithrombin III
- pyridoxine
- low-density lipoproteins
Status
Published
Research group
- Geriatric Medicine
- Clinical Coagulation, Malmö
- Rehabilitation medicine
- Stroke policy and quality register research
ISBN/ISSN/Other
- ISSN: 1502-7686