The Cell Physiology of Biphasic Insulin Secretion

Summary, in English

Glucose-stimulated insulin secretion consists of a transient first phase followed by a sustained second phase. Diabetes (type II) is associated with abnormalities in this release pattern. Here we review the evidence that biphasic insulin secretion reflects exocytosis of two functional subsets of secretory granules and the implications for diabetes.

• Author: Patrik Rorsman; Lena Eliasson; Erik Renström; Jesper Gromada; Sebastian Barg; Sven Göpel
• Department/s: Islet cell physiology; Diabetes - Islet Cell Exocytosis; Diabetes - Islet Patophysiology; Department of Experimental Medical Science
• Publishing year: 2000
• Language: English
• Pages: 72-77
• Publication/Series: News in Physiological Sciences
• Volume: 15
• Issue: 2
• Links: http://physiologyonline.physiology.org/cgi/content/full/15/2/72
• Document type: Journal article
• Publisher: American Physiological Society
• Topic: Endocrinology and Diabetes
• Status: Published
• Research group: Islet cell physiology; Diabetes - Islet Cell Exocytosis; Diabetes - Islet Patophysiology
• ISBN/ISSN/Other: ISSN: 1522-161X