Alpha-Synuclein Produces Early Behavioral Alterations Via Striatal Cholinergic Synaptic Dysfunction by Interacting with GluN2D N-Methyl-D-Aspartate Receptor Subunit.

Summary, in English

Advanced Parkinson's disease (PD) is characterized by massive degeneration of nigral dopaminergic neurons, dramatic motor and cognitive alterations, and presence of nigral Lewy bodies, whose main constituent is α-synuclein (α-syn). However, the synaptic mechanisms underlying behavioral and motor effects induced by early selective overexpression of nigral α-syn are still a matter of debate.

• Author: Alessandro Tozzi; Antonio de Iure; Vincenza Bagetta; Michela Tantucci; Valentina Durante; Ana Quiroga-Varela; Cinzia Costa; Massimiliano Di Filippo; Veronica Ghiglieri; Emanuele Claudio Latagliata; Michal Wegrzynowicz; Mickael Decressac; Carmela Giampà; Jeffrey W Dalley; Jing Xia; Fabrizio Gardoni; Manuela Mellone; Omar Mukhtar El-Agnaf; Mustafa Taleb Ardah; Stefano Puglisi-Allegra; Anders Björklund; Maria Grazia Spillantini; Barbara Picconi; Paolo Calabresi
• Department/s: Neurobiology; MultiPark: Multidisciplinary research focused on Parkinson´s disease
• Publishing year: 2015-08-20
• Language: English
• Publication/Series: Biological Psychiatry
• Links: http://www.ncbi.nlm.nih.gov/pubmed/26392130?dopt=Abstract; http://dx.doi.org/10.1016/j.biopsych.2015.08.013
• Document type: Journal article
• Publisher: Elsevier
• Topic: Neurosciences
• Status: Published
• Research group: Neurobiology
• ISBN/ISSN/Other: ISSN: 0006-3223