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Towards the modelling of ageing and atherosclerosis effects in ApoE(-/-) mice aortic tissue.

På svenska

Author

  • Tobias Waffenschmidt
  • Myriam Cilla
  • Pablo Sáez
  • Marta M Pérez
  • Miguel A Martínez
  • Andreas Menzel
  • Estefanía Peña

Summary, in English

The goal of this work consists in a quantitative analysis and constitutive modelling of ageing processes associated to plaque formation in mice arteries. Reliable information on the characteristic evolution of pressure-stretch curves due to the ageing effects is extracted from previous inflation test experiments. Furthermore, characteristic age-dependent material parameters are identified on the basis of a continuum-mechanics-based parameter optimisation technique. The results indicate that the aorta-stiffness of the healthy control mice remains basically constant irrespective of the diet-time and age. In contrast, significant differences exist within the material response and in consequence within the material parameters between the ApoE(-/-) and the control mice as well as for the different locations over the aorta which is underlined by our experimental observations. With regard to the temporal evolution of the material parameters, we observe that the material parameters for the ApoE(-/-) mice aortas exhibit a saturation-type increase with respect to age.

Department/s

Publishing year

2016-02-12

Language

English

Publication/Series

Journal of Biomechanics

Document type

Journal article

Publisher

Elsevier

Topic

  • Other Medical Biotechnology

Status

Published

ISBN/ISSN/Other

  • ISSN: 1873-2380