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Protein kinase Cα suppresses the expression of STC1 in MDA-MB-231 breast cancer cells

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Author

Summary, in English

Several protein kinase C (PKC) isoforms have been shown to influence different cellular processes that may contribute to the malignancy of breast cancer cells. To obtain insight into mechanisms mediating the PKC effects, global gene expression was analyzed in MDA-MB-231 breast cancer cells in which PKCα, PKCδ or PKCε had been down-regulated with siRNA. Gene set enrichment analyses revealed that hypoxia-induced genes were enriched among genes that increased in PKCα-down-regulated cells. The STC1 mRNA, encoding stanniocalcin 1, was particularly up-regulated following depletion of PKCα and was also induced by hypoxia. Both hypoxia and PKCα down-regulation also led to increased STC1 protein levels. The results demonstrate that PKCα suppresses the expression of STC1 in breast cancer cells

Department/s

Publishing year

2011

Language

English

Pages

1023-1030

Publication/Series

Tumour Biology

Volume

32

Issue

5

Document type

Journal article

Publisher

Springer

Topic

  • Cancer and Oncology

Keywords

  • Gene expression
  • Stanniocalcin 1
  • Protein kinase C
  • Breast cancer cells

Status

Published

ISBN/ISSN/Other

  • ISSN: 1423-0380