Fertility and female dietary exposure to persistent organochlorine compounds
Author
Summary, in English
It has been suggested that the time elapsed between the cessation of contraceptive use and clinical recognition of pregnancy (the time to pregnancy) is useful to investigate a couple's fertility. Once a pregnancy is clinically recognised, reproductive loss can be measured by the frequency of miscarriages and stillbirths.
Self-administered questionnaires were sent to the fishermen's wives and sisters from both coasts, and information was collected on each woman's first planned pregnancy. From a subgroup of women, blood samples were analysed for CB-153, a biomarker for POC.
Among the fishermen's wives, an increased time to pregnancy was found for the east coast women (i.e. the exposed women) compared to the west coast women. The increase was due to a doubled time to pregnancy among east coast women who smoked more than 10 cigarettes per day compared to west coast women with the same smoking habits. Among the fishermen's sisters no effect was found from cohort affiliation. Among the east coast fishermen's wives and sisters, no indications were found of a prolonged time to pregnancy for women who had a high current consumption of fatty fish, had grown up in a fishermans's family and/or fishing village, or had a high concentration of CB-153.
No increased miscarriage risk was found for the east compared to the west coast women. Neither did a high current fish consumption, growing up in a fisherman's family and/or fishing village, or a high concentration of CB-153 imply an increased risk for miscarriages.
Publishing year
2003
Language
English
Full text
- Available as PDF - 559 kB
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Document type
Dissertation
Publisher
Anna Axmon, Dept of Occupational and Environmental Medicine, University Hospital, SE-221 85 Lund, Sweden,
Topic
- Environmental Health and Occupational Health
Keywords
- industrial medicine
- Yrkesmedicin
- arbetsmiljömedicin
- Public health
- epidemiology
- Folkhälsa
- epidemiologi
- Occupational health
- DDE
- DDT
- dioxins
- polychlorinated biphenyls
- persistent organochlorine compounds
- stillbirths
- miscarriages
- Fertility
- time to pregnancy
Status
Published
Supervisor
- Lars Hagmar
- Ulf Strömberg
- Lars Rylander
ISBN/ISSN/Other
- ISBN: 91-628-5561-1
Defence date
14 March 2003
Defence time
10:15
Defence place
University Hospital in Lund (room F1).
Opponent
- Gösta Axelsson (Prof)