The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

5-(2 '-oxoheptadecyl)-resorcinol and 5-(2 '-oxononadecyl)-resorcinol, cytotoxic metabolites from a wood-inhabiting basidiomycete

På svenska

Author

Summary, in English

5-(2'-oxoheptadecyl)-resorcinol (1) and 5-(2'-oxononadecyl)-resorcinol (2) were isolated from fermentations of an imperfect basidiomycete. The structures of the compounds were determined by spectroscopic techniques. Both compounds exhibit cytotoxic effects against the human colon tumor cell lines COLO-320, DLD-1 and HT-29 and the human promyeloid leukemia cell line HL-60, the human leukemia T cell JURKAT, the human hepatocellular carcinoma cell line HEP-G2 as well as the J774 mouse macrophage cell line. The compounds induce morphological and physiological differentiation of HL-60 cells into granulocytes, which subsequently die by apoptosis. Both compounds show no antibacterial and antifungal activity.

Publishing year

2002

Language

English

Pages

1004-1008

Publication/Series

Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences

Volume

57

Issue

11-12

Document type

Journal article

Publisher

Verlag der Zeitschrift für Naturforschung

Topic

  • Organic Chemistry

Keywords

  • 5-(2'-oxoheptadecyl)-resorcinol and 5-(2'-oxononadecyl)-resorcinol
  • basidiomycete
  • cytotoxic activities

Status

Published

ISBN/ISSN/Other

  • ISSN: 0939-5075