Primary mesenchymal stem cells in human transplanted lungs are CD90/CD105 perivascularly located tissue-resident cells.

Summary, in English

Mesenchymal stem cells (MSC) have not only been implicated in the development of lung diseases, but they have also been proposed as a future cell-based therapy for lung diseases. However, the cellular identity of the primary MSC in human lung tissues has not yet been reported. This study therefore aimed to identify and characterise the 'bona fide' MSC in human lungs and to investigate if the MSC numbers correlate with the development of bronchiolitis obliterans syndrome in lung-transplanted patients.

• Author: Sara Rolandsson Enes; Annika Andersson Sjöland; Jan Claas Brune; Hongzhe Li; Moustapha Kassem; Fredrik Mertens; Albert Westergren; Leif Eriksson; Lennart Hansson; Ingrid Skog; Leif Bjermer; Stefan Scheding; Gunilla Westergren-Thorsson
• Department/s: Lung Biology; Respiratory Medicine, Allergology, and Palliative Medicine; Stem Cell Center; Division of Clinical Genetics; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation; Department of Health Sciences; StemTherapy: National Initiative on Stem Cells for Regenerative Therapy; EpiHealth: Epidemiology for Health
• Publishing year: 2014
• Language: English
• Publication/Series: BMJ Open Respiratory Research
• Volume: 1
• Issue: 1
• Full text: - 4 MB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/25478178?dopt=Abstract; http://dx.doi.org/10.1136/bmjresp-2014-000027
• Document type: Journal article
• Publisher: BMJ Publishing Group
• Topic: Cell and Molecular Biology
• Status: Published
• Research group: Lung Biology
• ISBN/ISSN/Other: ISSN: 2052-4439