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A link between Helicobacter pylori and/or Chlamydia spp. infections and atherosclerosis

På svenska

Author

  • Magdalena Chmiela
  • Magdalena Kowlewicz-Kulbat
  • Aneta Miszczak
  • Monika Wisniewska
  • Tomasz Rechcinski
  • Katarzyna Kolodziej
  • Jaroslaw Kasprzak
  • Torkel Wadström
  • Wieslawa Rudnicka

Summary, in English

Antibodies to Helicobacter pylori, Chlamydia spp. and Mycobacterium bovis were determined in patients with coronary heart disease, H. pylori-related dyspepsia, and tuberculosis, and healthy controls. Enzyme-linked immunosorbent assay was conducted with a glycine extract and CagA protein of H. pylori, chlamydial lipopolysaccharide and mycobacterial heat shock protein Hsp65. The prevalence of anti-glycine extract IgG in coronary heart disease patients was higher than in the tuberculosis group and controls, and the same as in dyspeptic patients. Anti-chlamydial IgG were more prevalent in the coronary heart disease group than in healthy subjects. There was no difference in the prevalence of anti-CagA IgG in the coronary heart disease group and controls or anti-Hsp65 IgG in the patients with coronary heart disease, dyspepsia, tuberculosis, and controls. Anti-glycine extract IgA (like anti-glycine extract IgG) were more prevalent in the coronary heart disease group than in the healthy group. The highest anti-glycine extract IgG/IgA and anti-chlamydial IgG titers were more frequent in coronary heart disease patients as compared with controls. Infections with H. pylori and Chlamydia spp. and enhanced production of antibodies to these pathogens may predispose to human atherosclerosis. (C) 2003 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

Publishing year

2003

Language

English

Pages

187-192

Publication/Series

Pathogens and Disease

Volume

36

Issue

3

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Clinical Medicine

Keywords

  • Helicobacter pylori
  • Chlamydia spp.
  • atherosclerosis

Status

Published

ISBN/ISSN/Other

  • ISSN: 2049-632X