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Biological and genetic evolution of HIV type 1 in two siblings with different patterns of disease progression

På svenska

Author

  • Chiara Ripamonti
  • Thomas Leitner
  • Anna Laurén
  • Ingrid Karlsson
  • Angela Pastore
  • Mariangela Cavarelli
  • Liselotte Antonsson
  • Anna Plebani
  • Eva Maria Fenyö
  • Gabriella Scarlatti

Summary, in English

To investigate the immunological and virological factors that may lead to different patterns of disease progression characteristic of HIV-1-infected children, two HIV-1-infected siblings, a slow and a fast progressor, were followed prospectively before the onset of highly active antiretroviral therapy. Viral coreceptor usage, including the use of CCR5/CXCR4 chimeric receptors, macrophage tropism, and sensitivity to the CC-chemokine RANTES, has been studied. An autologous and heterologous neutralizing antibody response has been documented using peripheral blood mononuclear cells- and GHOST(3) cell line-based assays. Viral evolution was investigated by env C2-V3 region sequence analysis. Although both siblings were infected with HIV-1 of the R5 phenotype, their viruses showed important biological differences. In the fast progressor there was a higher RANTES sensitivity of the early virus, an increased trend to change the mode of CCR5 receptor use, and a larger genetic evolution. Both children developed an autologous neutralizing antibody response starting from the second year with evidence of the continuous emergence of resistant variants. A marked viral genetic and phenotypic evolution was documented in the fast progressor sibling, which is accompanied by a high viral RANTES sensitivity and persistent neutralizing antibodies.

Department/s

Publishing year

2007

Language

English

Pages

1531-1540

Publication/Series

AIDS Research and Human Retroviruses

Volume

23

Issue

12

Document type

Journal article

Publisher

Mary Ann Liebert, Inc.

Topic

  • Pharmacology and Toxicology
  • Basic Medicine
  • Microbiology in the medical area

Status

Published

Research group

  • Drug Target Discovery

ISBN/ISSN/Other

  • ISSN: 1931-8405