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TEC HOMOLOGY (TH) ADJACENT TO THE PH DOMAIN

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Author

Summary, in English

The pleckstrin homology (PH) domain is extended in the Btk kinase family by a region designated the TH (Tee homology) domain, which consists of about 80 residues preceding the SH3 domain. The TH domain contains a conserved 27 amino acid stretch designated the Btk motif and a proline-rich region. Sequence similarity was found to a putative Pas GTPase activating protein and a human interferon-gamma binding protein both in the PH domain and the Btk motif region. SLK1/SSP31 protein kinase and a non-catalytic p85 subunit of PI-3 kinase had similarity only with the proline rich region. The identification of a PH domain extension in some signal transduction proteins in different species suggests that this region is involved in protein-protein interactions.

Publishing year

1994

Language

English

Pages

263-265

Publication/Series

FEBS Letters

Volume

350

Issue

2-3

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Biological Sciences

Keywords

  • CYTOPLASMIC TYROSINE KINASE
  • SIGNAL TRANSDUCTION
  • BTK
  • BRUTONS AGAMMAGLOBULINEMIA TYROSINE KINASE
  • XLA
  • X-LINKED AGAMMAGLOBULINEMIA

Status

Published

ISBN/ISSN/Other

  • ISSN: 1873-3468