Deregulation of protein phosphatase expression in acute myeloid leukemia
Author
Summary, in English
Acute myeloid leukemia (AML) is a highly malignant disease of myeloid cell line. AML is the most frequent adult leukemia with inadequate treatment possibility. The protein phosphatases are critical regulators of cell signaling, and deregulation of protein phosphatases always contribute to cell transformation. Although many studies established a relationship between protein phosphatases and leukemia, little is known about the role of this group of proteins in AML. To address this issue, we initially identified the complete catalog of human protein phosphatase genes and used this catalog to study deregulation of protein phosphatases in AML. Using mRNA expression data of AML patients, we show that 11 protein phosphatases are deregulated in AML within 174 protein phosphatases. The GO enrichment study suggests that these genes are involved in multiple biological processes other than protein de-phosphorylation. Expression of DUSP10, PTPRC, and PTPRE was significantly higher than average expression in AML, and a linear combination of DUSP10, MTMR11, PTPN4, and PTPRE expressions provides important information about disease subtypes. Our results provide an overview of protein phosphatase deregulation in AML.
Department/s
- Department of Translational Medicine
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
Publishing year
2013
Language
English
Publication/Series
Medical Oncology
Volume
30
Issue
2
Full text
- Available as PDF - 1000 kB
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Document type
Journal article
Publisher
Humana Press
Topic
- Cancer and Oncology
Keywords
- Dual specificity
- Protein serine/threonine phosphatase
- phosphatase
- Protein tyrosine
- Protein phosphatase
- Acute myeloid leukemia
- AML
Status
Published
ISBN/ISSN/Other
- ISSN: 1559-131X