The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Low glutathione peroxidase in rdl mouse retina increases oxidative stress and proteases

På svenska

Author

  • Poonam Ahuja-Jensen
  • Siv Johnsen-Soriano
  • Satpal Ahuja
  • Francisco Bosch-Morell
  • Maria Sancho-Tello
  • Francisco Javier Romero
  • Magnus Abrahamson
  • Theo van Veen

Summary, in English

Malondialdehyde, reduced glutathione, glutathione peroxidase, glutathione reductase and cysteine protease cathepsins at postnatal (PN) days 2, 7, 14, 21 and 28 in controls (wt) and the retinal degeneration 1 (rd1) mouse model for retinitis pigmentosa retinas were measured to determine oxidative stress. In PN28 wt and PN2 rd1 retinas, elevated malondialdehyde and low glutathione peroxidase activity indicate higher oxidative load, despite higher reduced glutathione in PN2 rd1 retinas. This is due to physiological exposure to light and retinal vascular/neural restructuring, respectively. Compared with wt retinas, relatively high malondialdehyde at PN2 and cathepsin levels at PN14, 21 and 28 in rd1 retinas indicate that cells of the residual inner retina also contribute to the oxidative stress and retinal degeneration.

Publishing year

2007

Language

English

Pages

797-801

Publication/Series

NeuroReport

Volume

18

Issue

8

Document type

Journal article

Publisher

Lippincott Williams & Wilkins

Topic

  • Neurosciences

Keywords

  • retinal degeneration
  • stress
  • oxidative
  • malondialdehyde
  • cysteine protease
  • glutathione system
  • rd1 mice

Status

Published

Research group

  • Family Medicine and Community Medicine

ISBN/ISSN/Other

  • ISSN: 1473-558X