A pilot study of facial, cranial and brain MRI morphometry in men with schizophrenia: Part 2.
Author
Summary, in English
This pilot study applies a new 3D morphometric MR method to test the hypothesis that men with schizophrenia (vs. controls) have deviant facial shapes and landmark relations in cranio/facialibrain (CFB) regions. This constitutes Part 2 of paired articles in this issue of Psychiatry Research: Neuroimaging, in which Part 1 presents the new method in detail. MRI coordinates from CFB landmarks of 23 patients and 15 controls were identified and then aligned with the Procrustes model, leaving shape as the only unitless geometrical information. Men with schizophrenia had significantly longer mid- and lower-facial heights, and greater lower (left) facial depth, with a tendency toward rotation along the facial midline. This supports findings from earlier anthropometric and 3D studies of the "exterior" (face). In contrast, none of the patient-control differences for the new "interior" (cranial-brain) distances reached statistical significance. These results need to be retested on a larger sample of both sexes. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
Department/s
Publishing year
2006
Language
English
Pages
187-195
Publication/Series
Psychiatry Research
Volume
147
Issue
2-3
Links
Document type
Journal article
Publisher
Elsevier
Topic
- Psychiatry
Keywords
- morphometry
- magnetic resonance imaging
- schizophrenia
- shape
- cranio-facial landmarks
Status
Published
ISBN/ISSN/Other
- ISSN: 1872-7123