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The Expression of β-Microseminoprotein but Not CRISP3 Is Reduced in Ovarian Cancer and Correlates to Survival.

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Author

Summary, in English

β-Microseminoprotein (MSMB) is an abundant protein in seminal plasma. Most of it is present as a free protein but a small part is bound to cysteine-rich secretory protein 3 (CRISP3) as a non-covalent complex. Even though their physiological function is unknown, both MSMB and CRISP3 have been ascribed roles in prostate carcinogenesis. Thus, several recent experimental studies indicate a tumor-suppressor role for MSMB. The present study was undertaken in order to evaluate, for the first time, the expression of MSMB and CRISP3 in ovaries and in ovarian tumors and to determine if their expression might indicate a role in ovarian tumor development.

Publishing year

2012

Language

English

Pages

3993-3999

Publication/Series

Anticancer research

Volume

32

Issue

9

Document type

Journal article

Publisher

International Institute of Cancer Research

Topic

  • Cancer and Oncology

Keywords

  • CRISP3
  • beta-Microseminoprotein
  • immunohistochemistry
  • ovary
  • ovarian
  • cancer
  • survival

Status

Published

Research group

  • Urogynaecology and Reproductive Pharmacology
  • Clinical Chemistry, Malmö

ISBN/ISSN/Other

  • ISSN: 1791-7530