From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications

Summary, in English

This article reviews the regulation of production of RBCs at several levels. We focus on the regulated expansion of burst-forming unit-erythroid erythroid progenitors by glucocorticoids and other factors that occur during chronic anemia, inflammation, and other conditions of stress. We also highlight the rapid production of RBCs by the coordinated regulation of terminal proliferation and differentiation of committed erythroid colony-forming unit-erythroid progenitors by external signals, such as erythropoietin and adhesion to a fibronectin matrix. We discuss the complex intracellular networks of coordinated gene regulation by transcription factors, chromatin modifiers, and miRNAs that regulate the different stages of erythropoiesis. (Blood. 2011;118(24):6258-6268)

• Author: Shilpa M. Hattangadi; Piu Wong; Lingbo Zhang; Johan Flygare; Harvey F. Lodish
• Department/s: Division of Molecular Medicine and Gene Therapy; StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
• Publishing year: 2011
• Language: English
• Pages: 6258-6268
• Publication/Series: Blood
• Volume: 118
• Issue: 24
• Links: http://dx.doi.org/10.1182/blood-2011-07-356006
• Document type: Journal article review
• Publisher: American Society of Hematology
• Topic: Hematology
• Status: Published
• ISBN/ISSN/Other: ISSN: 1528-0020