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Novel method for the synthesis of molecularly imprinted polymer bead libraries

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Author

Summary, in English

A novel method for the synthesis of spherical molecularly imprinted polymer (MIP) beads by suspension polymerization in mineral oil is described. The usefulness of the method was demonstrated by the synthesis of a propranolol imprinted MIP library. The composition of the library was generated by statistical experimental design. Multivariate data analysis correlated the screening data, obtained by a radioligand binding assay, to the composition of the MIPs.

Publishing year

2004

Language

English

Pages

315-320

Publication/Series

Macromolecular Rapid Communications

Volume

25

Issue

1

Document type

Journal article

Publisher

John Wiley & Sons Inc.

Topic

  • Pharmacology and Toxicology

Keywords

  • bead
  • spherical
  • molecular imprinting
  • chemometrics
  • combinatorial library
  • suspension polymerization

Status

Published

Research group

  • Nanomedicine and Biomaterials

ISBN/ISSN/Other

  • ISSN: 1022-1336