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Hematopoietic stem cell aging: Mechanism and consequence

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Author

Summary, in English

Advancing age is frequented by the onset of a variety of hematological conditions characterized by diminished homeostatic control of blood cell production. The fact that upstream hematopoietic stem and progenitor cells are obligate mediators of homeostatic control of all blood lineages, has implicated the involvement of these cells in the pathophysiology of these conditions. Indeed, evidence from our group and others has suggested that two of the most clinically significant age-associated hematological conditions, namely, the diminution of the adaptive immune system and the elevated incidence of myeloproliferative diseases, have their origin in cell autonomous changes in the functional capacity of hematopoietic stem cells.

Publishing year

2007

Language

English

Pages

385-390

Publication/Series

Experimental Gerontology

Volume

42

Issue

5

Document type

Journal article

Publisher

Elsevier

Topic

  • Gerontology, specializing in Medical and Health Sciences

Keywords

  • lineage
  • myeloid
  • lymphoid
  • side population
  • stem cell
  • aging
  • potential
  • leukemia

Status

Published

Research group

  • Immunology

ISBN/ISSN/Other

  • ISSN: 1873-6815