A major population of mucosal memory CD4(+) T cells, coexpressing IL-18Rα and DR3, display innate lymphocyte functionality.
Author
Summary, in English
Mucosal tissues contain large numbers of memory CD4(+) T cells that, through T-cell receptor-dependent interactions with antigen-presenting cells, are believed to have a key role in barrier defense and maintenance of tissue integrity. Here we identify a major subset of memory CD4(+) T cells at barrier surfaces that coexpress interleukin-18 receptor alpha (IL-18Rα) and death receptor-3 (DR3), and display innate lymphocyte functionality. The cytokines IL-15 or the DR3 ligand tumor necrosis factor (TNF)-like cytokine 1A (TL1a) induced memory IL-18Rα(+)DR3(+)CD4(+) T cells to produce interferon-γ, TNF-α, IL-6, IL-5, IL-13, granulocyte-macrophage colony-stimulating factor (GM-CSF), and IL-22 in the presence of IL-12/IL-18. TL1a synergized with IL-15 to enhance this response, while suppressing IL-15-induced IL-10 production. TL1a- and IL-15-mediated cytokine induction required the presence of IL-18, whereas induction of IL-5, IL-13, GM-CSF, and IL-22 was IL-12 independent. IL-18Rα(+)DR3(+)CD4(+) T cells with similar functionality were present in human skin, nasal polyps, and, in particular, the intestine, where in chronic inflammation they localized with IL-18-producing cells in lymphoid aggregates. Collectively, these results suggest that human memory IL-18Rα(+)DR3(+) CD4(+) T cells may contribute to antigen-independent innate responses at barrier surfaces.Mucosal Immunology advance online publication, 1 October 2014; doi:10.1038/mi.2014.87.
Department/s
- Mucosal Immunology
- Leukocyte Migration
- Airway Inflammation and Immunology
- Urology
- Urological research, Malmö
- Internal Medicine - Epidemiology
- Medicine, Lund
- Dermatology and Venereology (Lund)
Publishing year
2015
Language
English
Pages
545-558
Publication/Series
Mucosal Immunology
Volume
8
Issue
3
Full text
Links
Document type
Journal article
Publisher
Nature Publishing Group
Topic
- Immunology in the medical area
Status
Published
Research group
- Mucosal Immunology
- Leukocyte Migration
- Airway Inflammation and Immunology
- Urology
- Urological research, Malmö
- Internal Medicine - Epidemiology
ISBN/ISSN/Other
- ISSN: 1933-0219