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Spare respiratory capacity, oxidative stress and excitotoxicity

Author

Summary, in English

Chronic exposure to glutamate (glutamate excitotoxicity) exacerbates neuronal damage in the aftermath of stroke and is implicated in a variety of neurodegenerative disorders. mitochondria play a central role in the survival or death of the exposed neuron. calcium, oxidative stress and ATP insufficiency play closely interlocked roles that may be investigated with primary neuronal cultures.

Publishing year

2009

Language

English

Pages

1385-1388

Publication/Series

Biochemical Society Transactions

Volume

37

Document type

Journal article

Publisher

Biochemical Society

Topic

  • Biochemistry and Molecular Biology

Keywords

  • oxidative
  • mitochondrion
  • ischaemia
  • glutamate
  • ATP
  • excitotoxicity
  • stress

Status

Published

ISBN/ISSN/Other

  • ISSN: 0300-5127