Spare respiratory capacity, oxidative stress and excitotoxicity
Author
Summary, in English
Chronic exposure to glutamate (glutamate excitotoxicity) exacerbates neuronal damage in the aftermath of stroke and is implicated in a variety of neurodegenerative disorders. mitochondria play a central role in the survival or death of the exposed neuron. calcium, oxidative stress and ATP insufficiency play closely interlocked roles that may be investigated with primary neuronal cultures.
Department/s
Publishing year
2009
Language
English
Pages
1385-1388
Publication/Series
Biochemical Society Transactions
Volume
37
Document type
Journal article
Publisher
Biochemical Society
Topic
- Biochemistry and Molecular Biology
Keywords
- oxidative
- mitochondrion
- ischaemia
- glutamate
- ATP
- excitotoxicity
- stress
Status
Published
ISBN/ISSN/Other
- ISSN: 0300-5127