The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Trousseau's syndrome - what is the evidence? A population-based autopsy study

På svenska

Author

  • M Ogren
  • D Bergqvist
  • K Wahlander
  • H Eriksson
  • Nils Sternby

Summary, in English

Despite numerous studies documenting the association between cancer and venous thromboembolism (VTE), the reason for the excessive risk in certain cancers remains obscure. No large-scale studies have yet investigated the independent effects of cancer type, site and growth pattern. Between 1970 and 1982, 23,796 standardised autopsies were performed, representing 84% of all in-hospital deaths in an urban Swedish population. The relationship between cancer and PE was evaluated with logistic regression. The overall PE prevalence was 23%, and 10% of the population had a fatal PE. Forty-two per cent of pancreatic cancer patients had PE (OR 2.55; 95% CI 2.10-3.09) (p < 0.001); gall bladder, gastric, colorectal and pulmonary adenocarcinomas were similarly independently associated with PE. In comparison with squamous cell lung cancer, patients with pulmonary adenocarcinoma had 1.65 times higher odds for PE (95% CI 1.20-2.29). Adenocarcinoma and metastatic cancer were independently associated with PE risk (OR 1.27; 95% CI 1.16 - 1.40; P < 0.001, and OR 1.10; 95% CI 1.01 - 1.20; p=0.024, respectively) but when controlling for cancer type and spread, pancreatic cancer was still associated with an OR of 2.10 (95% CI 1.71-2.58) of PE (p < 0.001).We conclude that the risk of PE in cancer patients depends not only on the cancer site and spread but also on the histological type. The excess independent risk in pancreatic cancer is intriguing and should warrant further research.

Department/s

Publishing year

2006

Language

English

Pages

541-545

Publication/Series

Thrombosis and Haemostasis

Volume

95

Issue

3

Document type

Journal article

Publisher

Schattauer GmbH

Topic

  • Cardiac and Cardiovascular Systems

Keywords

  • clinical/epidemiological studies
  • malignancy
  • pulmonary embolism

Status

Published

Research group

  • Pathology, Malmö

ISBN/ISSN/Other

  • ISSN: 0340-6245