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Eosinophil lysis and free granules: an in vivo paradigm for cell activation and drug development

På svenska

Author

Summary, in English

Release of cytotoxic granule proteins from activated eosinophil granules is considered to be a key pathogenic mechanism in eosinophilic diseases. Degenerated eosinophils and extracellular eosinophil granules have been repeatedly depicted. The present overview describes evidence that eosinophil lysis and distribution of free eosinophil granules (as opposed to 'classical degranulation') is an important mechanism by which eosinophils affect their surroundings. Here, Carl Persson and Jonas Erjefalt summarize how recent reports on the induction of eosinophil lysis in vivo provide a new paradigm for eosinophil activation and thus constitute a novel basis for pharmacological manipulations in eosinophilic diseases.

Publishing year

1997

Language

English

Pages

117-123

Publication/Series

Trends in Pharmacological Sciences

Volume

18

Issue

4

Document type

Journal article

Publisher

Elsevier

Topic

  • Pharmacology and Toxicology
  • Medicinal Chemistry
  • Immunology in the medical area

Status

Published

Research group

  • Airway Inflammation and Immunology

ISBN/ISSN/Other

  • ISSN: 0165-6147