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The assessment of serum-mediated phagocytosis of necrotic material by polymorphonuclear leukocytes to diagnose and predict the clinical features of systemic lupus erythematosus: an observational longitudinal study

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Author

Summary, in English

Serum-mediated phagocytosis of antibody- and complement-opsonized necrotic cell material (NCM) by polymorphonuclear leukocytes can be quantified by using a flow cytometry–based assay. The phagocytosis of necrotic cell material (PNC) assay parallels the well-known lupus erythematosus cell test. In this study, we aimed to investigate the diagnostic accuracy of the assay and the relationship with clinical manifestations and disease activity in systemic lupus erythematosus (SLE).

Publishing year

2016

Language

English

Publication/Series

Arthritis Research and Therapy

Volume

18

Document type

Journal article

Publisher

BioMed Central (BMC)

Topic

  • Rheumatology and Autoimmunity

Keywords

  • Systemic lupus erythematosus
  • Biomarkers
  • Diagnostic accuracy
  • Flow cytometry
  • Disease activity
  • Lupus nephritis

Status

Published

Research group

  • Joint and Soft Tissue Unit
  • Orthopedics - Clinical and Molecular Osteoporosis Research

ISBN/ISSN/Other

  • ISSN: 1478-6362