Penile intraepithelial neoplasia: Results of photodynarnic therapy

Summary, in English

Failure of response to treatment or recurrent disease is often noted in patients with penile intraepithelial neoplasia. Photodynamic therapy has recently been added to the list of treatment modalities used for this diagnosis. Our primary objective was to study the results of photodynamic therapy in the treatment of penile intraepithelial neoplasia in men over the age of 40 years. Ten patients aged 42-82 years with histopathologically confirmed lesions were studied. Lesions initially responded to photodynamic therapy in 7 out of 10 patients. Four of these patients presented no recurrences during a mean follow-up of 35 months, and were completely cleared after 2-8 treatments (mean 4.5 treatments). Three patients presented recurrences after treatment. No patient developed invasive penile cancer (mean follow-up 46.5 months). Photodynamic therapy is an alternative in the treatment of penile intraepithelial neoplasia, although prospective randomized trials are required to provide therapeutic guidelines.

• Author: John Paoli; Annika Ternesten Bratel; Gun-Britt Lowhagen; Bo Stenquist; Ola Forslund; Ann-Marie Wennberg
• Department/s: Clinical Microbiology, Malmö
• Publishing year: 2006
• Language: English
• Pages: 418-421
• Publication/Series: Acta Dermato-Venereologica
• Volume: 86
• Issue: 5
• Links: http://dx.doi.org/10.2340/00015555-0130
• Document type: Journal article
• Publisher: Medical Journals Limited
• Topic: Dermatology and Venereal Diseases
• Keywords: papilloma virus; human; erythroplasia of Queyrat; Bowen's disease; bowenoid papulosis; lichen sclerosus
• Status: Published
• Research group: Clinical Microbiology, Malmö
• ISBN/ISSN/Other: ISSN: 1651-2057