Synthesis of (-)-pregaliellalactone, conversion of (-)-pregaliellalactone to (-)-galiellalactone by mycelia of Galiella rufa

Summary, in English

An enantioselective synthesis of (-)-pregaliellalactone (1), a biosynthetic precursor of the potent fungal metabolite ( -)-galiellalactone (3) produced by several ascomycetes, is reported. When fed to a culture of Galiella rufa, 1 was efficiently converted to 3. (C) 2002 Elsevier Science Ltd. All rights reserved.

• Author: Martin H Johansson; B Kopcke; H Anke; Olov Sterner
• Department/s: Centre for Analysis and Synthesis
• Publishing year: 2002
• Language: English
• Pages: 2523-2528
• Publication/Series: Tetrahedron
• Volume: 58
• Issue: 13
• Links: http://dx.doi.org/10.1016/S0040-4020(02)00134-5
• Document type: Journal article
• Publisher: Elsevier
• Topic: Organic Chemistry
• Keywords: pregaliellalactone; stannylation; Diels-Alder cyclisation; Galiella rufa; galiellalactone
• Status: Published
• ISBN/ISSN/Other: ISSN: 0040-4020