The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Antibody response to IgA-binding streptococcal M proteins in children with IgA nephropathy

På svenska

Author

Summary, in English

Methods. Blood samples from patients with IgAN (n = 21) and age-matched controls (n = 83) were assayed by ELISA to detect an IgG antibody response to the IgA-BRs of the M4, M22 and M60 proteins. Antibodies were assayed for each IgA-BR separately and the results were combined. Results. Antibody levels to the IgA-BRs were significantly higher in IgAN patients than controls (P = 0.016), particularly in patients with recent streptococcal infection (P = 0.008). Conclusions. The results suggest that children with IgAN had a previous infection with a streptococcal strain expressing an IgA-binding M protein.

Publishing year

2010

Language

English

Pages

3434-3436

Publication/Series

Nephrology Dialysis Transplantation

Volume

25

Issue

10

Document type

Journal article

Publisher

Oxford University Press

Topic

  • Urology and Nephrology

Keywords

  • IgA nephropathy
  • children
  • group A streptococci
  • M protein

Status

Published

Research group

  • Pediatric Nephrology

ISBN/ISSN/Other

  • ISSN: 1460-2385