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Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium.

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Author

  • Robert Koivula
  • Alison Heggie
  • Anna Barnett
  • Henna Cederberg
  • Tue H Hansen
  • Anitra D Koopman
  • Martin Ridderstråle
  • Femke Rutters
  • Henrik Vestergaard
  • Ramneek Gupta
  • Sanna Herrgård
  • Martijn W Heymans
  • Mandy H Perry
  • Simone Rauh
  • Maritta Siloaho
  • Harriet J A Teare
  • Barbara Thorand
  • Jimmy Bell
  • Søren Brunak
  • Gary Frost
  • Bernd Jablonka
  • Andrea Mari
  • Tim J McDonald
  • Jacqueline M Dekker
  • Torben Hansen
  • Andrew Hattersley
  • Markku Laakso
  • Oluf Pedersen
  • Veikko Koivisto
  • Hartmut Ruetten
  • Mark Walker
  • Ewan Pearson
  • Paul Franks
Show all

Summary, in English

The DIRECT (Diabetes Research on Patient Stratification) Study is part of a European Union Framework 7 Innovative Medicines Initiative project, a joint undertaking between four industry and 21 academic partners throughout Europe. The Consortium aims to discover and validate biomarkers that: (1) predict the rate of glycaemic deterioration before and after type 2 diabetes onset; (2) predict the response to diabetes therapies; and (3) help stratify type 2 diabetes into clearly definable disease subclasses that can be treated more effectively than without stratification. This paper describes two new prospective cohort studies conducted as part of DIRECT.

Publishing year

2014

Language

English

Pages

1132-1142

Publication/Series

Diabetologia

Volume

57

Issue

6

Document type

Journal article

Publisher

Springer

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Genetic and Molecular Epidemiology
  • Diabetes - Clinical Obesity

ISBN/ISSN/Other

  • ISSN: 1432-0428