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Identification of novel transcription factor-like gene from human intestinal cells

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Author

  • K Lindfors
  • T Halttunen
  • P Huotari
  • N Nupponen
  • Mauno Vihinen
  • T Visakorpi
  • M Maki
  • H Kainulainen

Summary, in English

Intestinal crypt epithelial T84 cells form luminal structures and differentiate to intestinal enterocyte-like cells in response to IMR-90 fibroblast-secreted transforming growth factor-beta when grown within three-dimensional collagen gel. In search of TGF-beta regulated genes involved in this differentiation process, we isolated a TGF-beta downregulated cDNA, human homologue of rat apoptosis antagonising transcription factor that codes for a 560-amino-acid protein. Human AATF-mRNA was expressed at high levels in human brain, heart, thymus, kidney, and placenta while in skeletal muscle and colon the expression was lower. The gene was mapped to chromosome 17q11.2-q12. (C) 2000 Academic Press.

Publishing year

2000

Language

English

Pages

660-666

Publication/Series

Biochemical and Biophysical Research Communications

Volume

276

Issue

2

Document type

Journal article

Publisher

Elsevier

Topic

  • Biological Sciences

Keywords

  • TGF-beta
  • differentiation
  • transcription factor
  • AATF

Status

Published

ISBN/ISSN/Other

  • ISSN: 1090-2104