Microbial Translocation Correlates with the Severity of Both HIV-1 and HIV-2 Infections

Summary, in English

Microbial translocation has been linked to systemic immune activation during human immunodeficiency virus (HIV) type 1 infection. Here, we show that an elevated level of microbial translocation, measured as plasma lipopolysaccharide (LPS) concentration, correlates with AIDS in both individuals infected with HIV type 1 and individuals infected with HIV type 2. LPS concentration also correlates with CD4(+) T cell count and viral load independently of HIV type. Furthermore, elevated plasma LPS concentration was found to be concomitant with defective innate and mitogen responsiveness. We suggest that microbial translocation may contribute to loss of CD4(+) T cells, increase in viral load, and defective immune stimuli responsiveness during both HIV type 1 and HIV type 2 infections.

• Author: Salma Nowroozalizadeh; Fredrik Månsson; Zacarias da Silva; Johanna Repits; Braima Dabo; Carla Pereira; Antonio Biague; Jan Albert; Jens Nielsen; Peter Aaby; Eva Maria Fenyö; Hans Norrgren; Birgitta G Holmgren; Marianne Jansson
• Department/s: Infectious Diseases Research Unit; Division of Medical Microbiology; Infection Medicine (BMC); HIV-1 and HIV-2 host interactions; EpiHealth: Epidemiology for Health
• Publishing year: 2010
• Language: English
• Pages: 1150-1154
• Publication/Series: Journal of Infectious Diseases
• Volume: 201
• Issue: 8
• Links: https://www.jstor.org/stable/pdf/40599263.pdf
• Document type: Journal article
• Publisher: Oxford University Press
• Topic: Infectious Medicine
• Conference name: 5th Smögen Symposium on Virology
• Conference date: 2009-08-20 - 2009-08-22
• Conference place: Smögen, Sweden
• Status: Published
• Research group: Infectious Diseases Research Unit; HIV-1 and HIV-2 host interactions
• ISBN/ISSN/Other: ISSN: 1537-6613