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Does Helicobacter pylori infection per se cause gastric cancer or duodenal ulcer? Inadequate evidence in Mongolian gerbils and inbred mice

På svenska

Author

  • Duan Chen
  • Bjorn Stenstrom
  • Chun-Mei Zhao
  • Torkel Wadström

Summary, in English

A role for Helicobacter pylori infection in the development of gastric cancer in humans is well established; however, evidence for its carcinogenicity in animals remains inadequate. Mongolian gerbils and mice are commonly used to investigate the carcinogenicity of H. pylori, yet it is unclear whether H. pylori infection per se causes gastric cancer or duodenal ulcers in these animal models. Gastric adenocarcinoma in the gerbils was reported over 10 years ago, but this species has proved an unreliable model for studying H. pylori infection-associated gastric cancer. Helicobacter pylori infection alone appears insufficient to induce gastric cancer in these animals; additional carcinogenic insult is required. The development of invasive adenocarcinoma in inbred mice is rare regardless of the mouse or bacterial strain, and many long-term studies have failed to induce gastric cancer in these animals. Helicobacter pylori infection is also an established causative factor for duodenal ulcer in humans. However, few studies have attempted to develop animal models of H. pylori infection-induced duodenal ulcer. We therefore conclude that both Mongolian gerbils and inbred mice may be inadequate models for studying H. pylori infection-associated gastric cancer and that there is no animal model of H. pylori infection-induced duodenal ulcer.

Publishing year

2007

Language

English

Pages

184-189

Publication/Series

Pathogens and Disease

Volume

50

Issue

2

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Microbiology in the medical area

Keywords

  • ulcer
  • duodenal
  • gastric cancer
  • mice
  • Helicobacter pylori
  • Mongolian gerbils

Status

Published

ISBN/ISSN/Other

  • ISSN: 2049-632X