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Non-Viral Deoxyribonucleoside Kinases - Diversity and Practical Use

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Author

Summary, in English

Deoxyribonucleoside kinases (dNKs) phosphorylate deoxyribonucleosides to their corresponding monophosphate compounds. dNks also phosphorylate deoxyribonucleoside analogues that are used in the treatment of cancer or viral infections. The study of the mammalian dNKs has therefore always been of great medical interest. However, during the last 20 years, research on dNKs has gone into non-mammalian organisms. In this review, we focus on non-viral dNKs, in particular their diversity and their practical applications. The diversity of this enzyme family in different organisms has proven to be valuable in studying the evolution of enzymes. Some of these newly discovered enzymes have been useful in numerous practical applications in medicine and biotechnology, and have contributed to our understanding of the structural basis of nucleoside and nucleoside analogue activation.

Publishing year

2015

Language

English

Pages

235-248

Publication/Series

Journal of Genetics and Genomics

Volume

42

Issue

5

Document type

Journal article review

Publisher

Elsevier

Topic

  • Biological Sciences

Keywords

  • Nucleosides
  • Nucleotides
  • Nucleoside salvage pathway
  • Evolution
  • Suicide
  • gene therapy
  • Deoxynucleosides
  • Deoxynucleotides
  • Deoxynucleoside
  • kinases

Status

Published

ISBN/ISSN/Other

  • ISSN: 1673-8527