Young women with genital prolapse have a low collagen concentration
Author
Summary, in English
Background. Genital prolapse is a common and handicapping form of pelvic floor dysfunction. To explain its genesis as a result of endopelvic connective tissue weakness, the collagen state was analyzed in women with and without genital prolapse. Methods. Punch biopsies from the paraurethral ligaments were obtained during the operation from 22 women undergoing surgery for genital prolapse. As controls, similar biopsies were taken from 13 women who underwent gynecologic surgery for other benign reasons. Collagen concentration as hydroxyproline and its extractability by pepsin digestion were studied in relation to age by multiple regression, two-way ANOVA, Levene's test, and Student's t-test. Histological examination was also performed. Results. Women, younger than 53 years, with genital prolapse had a 30% lower collagen concentration than age-matched controls, which reached significance, P = 0.01. The extractability by pepsin digestion, an indicator of cross-links in the collagen molecule, did not significantly differ between groups. It did, however, decrease significantly with age in both prolapse patient and control groups. Morphology supported these findings with a less-dense extracellular matrix composition subepithelially in genital prolapse compared to a healthy control. Conclusion. For the first time, we show that young women with genital prolapse have a decreased collagen concentration, suggesting a different organization of the endopelvic connective tissue extracellular matrix. Furthermore, these alterations differ from those earlier found in younger women with stress urinary incontinence.
Department/s
- Matrix Biology
Publishing year
2004
Language
English
Pages
1193-1198
Publication/Series
Acta Obstetricia et Gynecologica Scandinavica
Volume
83
Issue
12
Links
Document type
Journal article
Publisher
Wiley-Blackwell
Topic
- Obstetrics, Gynecology and Reproductive Medicine
Keywords
- connective tissue
- age
- collagen
- genital prolapse
Status
Published
Research group
- Matrix Biology
ISBN/ISSN/Other
- ISSN: 1600-0412