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The Correlation of Polymorphism of Estrogen Receptor Gene to Dry Eye Syndrome in Postmenopausal Women

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Author

  • Yanling He
  • Xiaoxin Li,
  • Yongzhen Bao,
  • Jianmin Sun
  • Jinrong Liu

Summary, in English

PURPOSE: To investigate the correlation of estrogen receptor (ER) gene polymorphism to dry eye syndrome in postmenopausal women. METHODS: Xba I and Pvu II polymorphism of ER gene were studied by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 65 patients with dry eye syndrome and 73 with controls in postmenopausal women. RESULTS: There was a significant difference of Pvu II polymorphism of ER gene between the patients of dry eye syndrome and controls in postmenopausal women (P < 0.05), but no significant difference was found in Xba I polymorphism of ER gene (P > 0.05). CONCLUSION: There is a significant correlation of Pvu II polymorphism of ER gene with dry eye syndrome in postmenopausal women. It is indicated that the difference in ER genotypes might influence the development of dry eye syndrome.

Publishing year

2006

Language

Chinese

Pages

233-236

Publication/Series

Yanke xuebao (Visual Science)

Volume

22

Issue

4

Document type

Journal article

Publisher

Zhongshan Yike Daxue Zhongshan Yanke Zhongxin

Topic

  • Medicinal Chemistry

Status

Published

ISBN/ISSN/Other

  • ISSN: 1000-4432