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The biological and ethical basis of the use of human embryonic stem cells for in vitro test systems or cell therapy

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Author

  • Marcel Leist
  • Susanne Bremer
  • Patrik Brundin
  • Juergen Hescheler
  • Agnete Kirkeby
  • Karl-Heinz Krause
  • Peter Poerzgen
  • Michel Puceat
  • Mathias Schmidt
  • Andre Schrattenholz
  • Naomi B. Zak
  • Hannes Hentze
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Summary, in English

Human embryonic stern cells (hESC) are now routinely cultured in many laboratories, and differentiation protocols are available to generate a large variety of cell types. In all ongoing ethical debate opinions of different groups are based oil varying sets of religious, historical, cultural and scientific arguments as well as oil widely differing levels of general information. We here give all overview of the biological background for non-specialists, and address all issues of the current stern cell debate that are of concern in different cultures and states. Thirty-five chapters address embryo definition, potential killing and the beginning of human life, in addition to matters of human dignity, patenting, commercialisation, and potential alternatives for the future, such as induced pluripotent (reprogrammed) stern cells. All arguments art compiled in a synopsis, and compromise solutions, e.g. for the definition of the beginning of personhood and for assigning dignity to embryos, art suggested. Until recently, the major application of hESC was thought to be transplantation of cells derived from hESC for therapeutic use. We discuss here that the most likely immediate uses will rather be in vitro test systems and disease models. Major and minor pharmaceutical companies have entered this field, and the European Union is sponsoring academic research into hESC-based innovative test systems. This development is supported by new testing strategies in Europe and the USA focussing oil human cell-based in vitro systems for safety evaluations, and shifting the focus of toxicology away from classical animal experiments towards a more mechanistic understanding.

Publishing year

2008

Language

English

Pages

163-190

Publication/Series

ALTEX Alternatives To Animal Experimentation

Volume

25

Issue

3

Document type

Journal article

Publisher

Spektrum Akad Verlag

Topic

  • Neurosciences

Keywords

  • stem cell ethics
  • in vitro toxicology
  • human embryonic stem cells
  • iPs
  • cells

Status

Published

ISBN/ISSN/Other

  • ISSN: 0946-7785