Male infertility and prostate cancer risk: a nested case-control study.
Author
Summary, in English
The pathogenesis of prostate cancer is unclear, although experimental evidence implicates androgens as playing an important role. Infertile men frequently suffer from some degree of hypogonadism and may hence be hypothesized to be at lower risk of developing prostate cancer than fertile men. To test this hypothesis, we conducted a case-control study nested within "the Malmö Diet and Cancer Study" cohort in Sweden, inviting 661 prostate cancer cases and 661 age-matched controls to participate. Of the 975 (74%) respondents, we excluded 84 childless men with unknown fertility status. Thus, 891 men were included, providing 445 prostate cancer cases and 446 controls. Of these, 841 (94%) men were biological fathers and 50 (6%) men were infertile. Logistic regression showed that the infertile men were at significantly lower risk of being diagnosed with prostate cancer than the fertile men (odds ratio, 0.45; 95% confidence interval, 0.25-0.83). Conditional and unconditional multivariate models, adjusting for socioeconomic, anthropometric, and health-status-related factors, provided similar estimates. We conclude that enduring male infertility is associated with a reduced prostate cancer risk, thus corroborating the theory that normal testicular function, and hence most probably sufficient steroidogenesis, is an important contributing factor to the later development of this malignancy.
Department/s
- Reproductive medicine, Malmö
- Clinical Chemistry, Malmö
- Urological cancer, Malmö
- Division of Occupational and Environmental Medicine, Lund University
- Surgery
- Internal Medicine - Epidemiology
- EpiHealth: Epidemiology for Health
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
Publishing year
2010
Language
English
Pages
1635-1643
Publication/Series
Cancer Causes and Control
Volume
Jul 1
Full text
Links
Document type
Journal article
Publisher
Springer
Topic
- Cancer and Oncology
Status
Published
Research group
- Reproductive medicine, Malmö
- Clinical Chemistry, Malmö
- Urological cancer, Malmö
- Surgery
- Internal Medicine - Epidemiology
ISBN/ISSN/Other
- ISSN: 1573-7225