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The Effect of Muscle Loading on Skeletal Muscle Regenerative Potential An Update of Current Research Findings Relating to Aging and Neuromuscular Pathology

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Author

  • Fabrisia Ambrosio
  • Fawzi Kadi
  • Jan Lexell
  • G. Kelley Fitzgerald
  • Michael L. Boninger
  • Johnny Huard

Summary, in English

Skeletal muscle is a dynamic tissue with a remarkable ability to continuously respond to environmental stimuli. Among its adaptive responses is the widely investigated ability of skeletal muscle to regenerate after loading or injury or both. Although significant basic science efforts have been dedicated to better understand the underlying mechanism controlling skeletal muscle regeneration, there has been relatively little impact in the clinical approaches used to treat skeletal muscle injuries and wasting. The purpose of this review article is to provide an overview of the basic biology of satellite cell function in response to muscle loading and to relate these findings in the context of aging and neuromuscular pathology for the rehabilitation medicine specialist.

Department/s

Publishing year

2009

Language

English

Pages

145-155

Publication/Series

American Journal of Physical Medicine and Rehabilitation

Volume

88

Issue

2

Document type

Journal article review

Publisher

Lippincott Williams & Wilkins

Topic

  • Physiotherapy

Keywords

  • Exercise
  • Regeneration
  • Skeletal Muscle
  • Stem Cells
  • Satellite Cells

Status

Published

ISBN/ISSN/Other

  • ISSN: 1537-7385