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Assignment of gene for coagulation factor V to chromosome 1 in man and to chromosome 13 in rat

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Author

Summary, in English

Two different factor V cDNA fragments were used as hydridization probes in the chromosomal assignment of the human and rat factor V genes. A 1.6-kb EcoRI fragment was used as a hybridization probe to analyze a panel of human-rodent somatic cell hybrids. Cosegregation of factor V specific DNA restriction fragments with human chromosome 1 was observed. In addition, a panel of rat-mouse somatic cell hybrids was analyzed with another human factor V cDNA probe to localize the gene for rat coagulation factor V. In the rat, the gene for coagulation factor V was found to be located in chromosome 13. This is the first gene in the rat to be localized to chromosome 13.

Publishing year

1988

Language

English

Pages

14-509

Publication/Series

Somatic Cell and Molecular Genetics

Volume

14

Issue

5

Document type

Journal article

Publisher

Springer

Topic

  • Medicinal Chemistry

Keywords

  • DNA Probes
  • Molecular
  • Cloning
  • Pair 1
  • Human
  • *Chromosomes
  • *Chromosome Mapping
  • Animals
  • Southern
  • Blotting
  • Factor V/*genetics
  • Humans
  • Hybrid Cells
  • Nucleic Acid Hybridization
  • Rats
  • Research Support
  • Non-U.S. Gov't

Status

Published

Research group

  • Clinical Chemistry, Malmö

ISBN/ISSN/Other

  • ISSN: 0740-7750