High concentration of kynurenic acid in bile and pancreatic juice
Author
Summary, in English
Kynurenic acid (KYNA) is an agonist of the G-protein-coupled receptor GPR35, which is predominantly expressed in gastrointestinal tissues. The aim of this study was to determine the content of KYNA in gastric juice, bile and pancreatic juice and intestinal content. KYNA was determined by means of high performance liquid chromatography. The mean concentrations of KYNA in human gastric juice is 9.91 +/- A 0.71 nM in contrast to human bile (832.5 +/- A 204.1 and 306.8 +/- A 35.2 nM) obtained from patients with cholecystolithiasis and obstructive jaundice, respectively. In pigs, the KYNA levels in bile and pancreatic juice are 1,113.3 +/- A 63.34 and 757.0 +/- A 394.4 nM, respectively. The KYNA concentration increases along the digestive system, reaching 1,638 nM in the colon content. We suggest that the liver and pancreas affect the content of kynurenic acid in the lumen of the digestive tract.
Department/s
Publishing year
2009
Language
English
Pages
637-641
Publication/Series
Amino Acids
Volume
37
Issue
4
Document type
Journal article
Publisher
Springer
Topic
- Zoology
Keywords
- Gastric juice
- Kynurenic acid
- Bile
- Pancreatic juice
Status
Published
ISBN/ISSN/Other
- ISSN: 0939-4451