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Trophic Factor Gene Therapy for Parkinson's Disease

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Author

Summary, in English

Parkinson's disease (PD) is a chronic and progressive neurodegenerative movement disorder for which there is presently no cure. Pharmacological remedies targeting the dopaminergic network are relatively effective at ameliorating motor deficits, especially in the early stages of the disease, but none of these therapies are curative and many generate their own problems. Recent advances in PD research have demonstrated that gene delivery of trophic factors, glial cell line-derived neurotrophic factor (GDNF) and neurturin, in particular, can provide structural and functional recovery in rodent and nonhuman primate models of PD. Similar success has been gleaned in open-label clinical trials, although this has yet to be realized in double-blinded analyses. This work reviews the field of trophic factor gene delivery for PD. (C) 2013 Movement Disorder Society

Publishing year

2013

Language

English

Pages

96-109

Publication/Series

Movement Disorders

Volume

28

Issue

1

Document type

Journal article review

Publisher

John Wiley & Sons Inc.

Topic

  • Neurology

Keywords

  • Parkinson's disease
  • GDNF
  • neurturin
  • regeneration
  • neuroprotection

Status

Published

Research group

  • Neurobiology

ISBN/ISSN/Other

  • ISSN: 0885-3185