Molecular genetic characterization of the 11q13 breakpoint in a desmoplastic fibroma of bone
Author
Summary, in English
Desmoplastic fibroma (DFB) is a benign primary bone tumor that usually occurs in adolescents and young adults. The genetic information on DFB is very limited. We here present cytogenetic, fluorescence in situ hybridization and single nucleotide polymorphism array findings in a case that had a rearrangement involving chromosomes 11 and 19 at G-banding analysis. The results showed that the breakpoint in 11q was different from that in desmoplastic fibroblastomas, and a segment containing five genes was hemizygously deleted from 11q13.
Department/s
- Division of Clinical Genetics
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
Publishing year
2012
Language
English
Pages
410-413
Publication/Series
Cancer Genetics
Volume
205
Issue
7-8
Links
Document type
Journal article
Publisher
Elsevier
Topic
- Cancer and Oncology
Keywords
- Desmoplastic fibroma
- desmoplastic fibroblastoma
- FISH
- SNP array
- 11q13
Status
Published
ISBN/ISSN/Other
- ISSN: 2210-7762